GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY About Acetaminophen Overdose Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective Frontiers Liquid Chromatography Tandem Mass Spectrometry Analysis of Acetaminophen Covalent Binding to Glutathione S Transferases