Carnitine Shuttle an overview ScienceDirect Topics L Carnitine in Mitochondria Encyclopedia MDPI Role of L carnitine in the transportation of long chain fatty acid across the mitochondria membrane. Critical Role of Mitochondrial Fatty Acid Metabolism in Normal Cell Function and Pathological Conditions Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine