Nutrition, GH IGF 1 signaling, and cancer ScienceDirect IGF 1 and IGF 2 as Molecules Linked to Causes and Consequences of Obesity from Fetal Life to Adulthood: A Systematic Review How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin IGF 1 vs. HGH Which is Better for Growth and Fat Loss? HRT The GH IGF 1 axis in obesity: pathophysiology and therapeutic considerations Nature Reviews Endocrinology