How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin GH and IGF 1 Regulation of Three Metabolic Pathways. GH inhibits Download Scientific Diagram Insulin like growth factor 1 level is a poor diagnostic indicator of growth hormone deficiency Scientific Reports The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline Frontiers Growth hormone insulin like growth factor I axis in health and disease states: an update on the role of intra portal insulin