G 6 PD The Disorder L glutamine for sickle cell disease: Knight or pawn? Alina Sadaf, Charles T Quinn, 2020 In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Real Time Monitoring of Glutathione in Living Cells Reveals that High Glutathione Levels Are Required to Maintain Stem Cell Function: Stem Cell Reports Glucose 6 phosphate Dehydrogenase (G6PD) Deficiency Concise Medical Knowledge