Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Glutathione, Alcohol and drugs Acetaminophen Toxicity in Children: Diagnosis, Clinical Assessment, and Treatment of Acute Overingestion Consultant360 Acetylcysteine for Acetaminophen Poisoning New England Journal of Medicine