Melanoma Pictures: Skin Changes and What to Look For This lovely patient was thrilled with her beautiful result after laser treatment of oral melanotic macules. I share this case to educate: laser treatment requires accurate diagnosis, an understanding of the differential From melanocytes to melanomas Nature Reviews Cancer Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Pronunciation of Melanotic Definition of Melanotic