Sex differences in glutathione metabolism and acetaminophen toxicity Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen at low doses depletes airway glutathione and alters respiratory reflex responses Smith 2013 The FASEB Journal Wiley Online Library Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy