Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Sex differences in glutathione metabolism and acetaminophen toxicity Glutathione IV for Liver Detox: Support & Benefits AZ IV Medics TYLENOL Toxin Free Texan Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.